The role of oxidative stress markers in Indonesian chronic kidney disease patients: a cross sectional study

Background: Several aspects of chronic kidney disease (CKD) such as the incidence rate and mortality are concerning. Oxidative stress contributes to progression in patients with CKD; however, a specific correlation between several markers oxidative estimated glomerular filtration (eGFR) albumin-creatinine ratio (ACR) Indonesian population has not been sufficiently described yet. Methods: This study was an analytic observational sample 56 CKD Universitas Airlangga Hospital, Surabaya, Indonesia, from December 2019 – March 2020. The for investigated were urinary 8-hydroxy-2 deoxyguanosine (8-OHdG), serum symmetric dimethylarginine (SDMA) asymmetric (ADMA). correlations each variable analyzed using Pearson analysis. Results: There positive 8-OHdG eGFR (p=0.00, r=0.51); there negative ACR (p=0.025, r=-0.30). SDMA showed r=-0.648), while (p=0.03, r=0.349). ADMA r=-0.476). There significantly decreased but increased stage progressed (p=0.001, p=0.00, p = 0.00, respectively). Higher urine detected without history hemodialysis, whereas higher value hemodialysis p=0.004, respectively), diabetes mellitus (DM) had mean (p 0.000) yet lower (p=0.004 p=0.003, respectively). Conclusions: In 8-OHdG, SDMA, correlated levels. also significant difference levels among stages, dialysis vs non dialysis, DM patients.